Open positions

Scientist, NGS and Assay Development

About Tranquis Therapeutics:

Tranquis Therapeutics is a clinical stage biotech company based in the SF Bay Area. Tranquis discovers and develops innovative medicines with the potential to revolutionize the management of neurodegenerative and aging-related diseases and to dramatically reduce the burden these illnesses place on patients, families and societies worldwide.

Founded on groundbreaking neuro-immunology research from the laboratory of Professor Edgar Engleman, MD, at Stanford University, Tranquis’ novel therapeutic approach targets underlying myeloid immune cell dysfunction that has been linked to a variety of nervous system disorders.

The company’s portfolio is comprised of small molecules which cross the blood-brain barrier, and the lead therapeutic candidate has demonstrated highly encouraging effects in challenging preclinical models of Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia (FTD), Parkinson’s Disease (PD), and age-related cognitive impairment.

Primary Responsibilities:

We are seeking a talented, creative, and motivated Senior Research Associate or Scientist with deep expertise in molecular biology, single-cell sequencing, assay development, and mammalian cell biology aid in our quest to develop the next generation of therapeutic molecules. The candidate will have numerous opportunities for professional growth in a rapidly growing biotechnology start-up, which includes growing into a leadership role of increasing responsibilities and the ability to publish highly impactful work in peer reviewed journals.

  • Designs and conducts experiments, collects data, and analyzes results in support of the Company’s project development objectives, and provides/implements process or document improvements
  • Performs assays for single-cell genomic and transcriptomic experiments, with a focus on analysis of target-specific transcript levels
  • Develop, optimize and perform NGS workflow steps, including sample preparation, library preparation, amplification and sequencing
  • Implementing single-cell genomics and transcriptomic technologies towards clinically relevant questions and biomarker discovery
  • Analyzing large/diverse single-cell datasets in close collaboration with partners
  • Assume project responsibilities and effectively present updates, and communicate research plans and timelines
  • Effectively collaborate with members within a fully integrated team to facilitate execution on projects within established timelines
  • Foster a driven, fast-paced, dynamic, and fun environment in which to do rigorous science
  • Supervise and mentor junior research staff


  • BS, MS, PhD or equivalent in molecular biology, cell biology, molecular biology, biochemistry, immunology or related field
  • At least 5 years of experience working in an academic or industry lab, with a proven track record of hands-on experience developing single-cell analysis methods and workflows
  • Expert knowledge of scientific principles and concepts in molecular and cell biology, with specialized skills in NGS, PCR and single-cell applications
  • Experience in RNA-seq methods (e.g. Smartseq2, 10X) is preferred
  • Familiarity with computational biology tools
  • Advanced expertise in the latest molecular and cellular biology techniques
  • Ability to work collaboratively in a fast-paced, interdisciplinary research team
  • Excellent prioritization and organization skills
  • Excellent oral and written communication skills

By joining our small, highly-dedicated and motivated team, you will experience a culture that is inclusive, supportive, and humble, yet challenging. We set our egos aside to collaborate for the benefit of the team, and most importantly, the patients in need of new therapeutic options. Tranquis Therapeutics is a company with a passion for improving global health with an intense focus on enriching patients’ lives. We employ the industry’s best to create a corporate culture that is fun, humble, respectful, and fulfilling, and where employees feel that they are making a difference and feel inspired to bring their passion to work.

We are an equal opportunity employer that values diversity, equity, and inclusion. We consider all qualified applicants regardless of race, sex, gender identity or expression, sexual orientation, age, religion, national origin, marital status, veteran status, or ability status. We will ensure that individuals who are differently abled are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment as provided to other applicants or employees. Please contact us to request accommodation.

Our open positions are managed through our Human Resources department. Unsolicited resumes from recruiting agencies, in advance of a specified agreement, will not be accepted. Resumes sent directly to our employees or our consultants from recruiting organizations will also not be accepted as referrals and do not obligate us to pay fees.

Tranquis Therapeutics is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.